STRUCTURAL BIOLOGY

Structural biology has proven to be a highly efficient tool for drug discovery. It provides key insights for understanding the specific nature of the interaction between a target protein and its potential inhibitor. This helps to guide a drug design process that delivers more effective and specific inhibitors. VENENUM Biodesign utilizes structural biology for our collaborators to support the drug discovery process. Our Structural Biology capabilities include:

• Rational design based protein engineering for improved stability and solubility
• Homology-based molecular modeling
• Computational analysis of function-related conformational changes and structural basis of molecular recognition
• Computational docking, lead optimization (including virtual screening)
• Crystallization of target proteins and their complexes with drug candidates
• 3D structure determination by X-ray diffraction analysis