Venenum Biodesign

A Member of Genesis Biotechnology Group

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STRUCTURAL BIOLOGY


Structural biology has proven to be a highly effective tool for small molecule target identification, drug design, and optimization. It provides key insights for understanding the specific nature of the interaction between a target protein and its potential inhibitor or activator. We use structural biology to guide our target identification and medicinal chemistry optimization. Our Structural Biology capabilities include:

  • Rational design based protein engineering for improved stability and solubility
  • Homology-based molecular modeling
  • Computational analysis of function-related conformational changes and structural basis of molecular recognition
  • Computational docking, lead optimization (including virtual screening)
  • Crystallization of target proteins and their complexes with drug candidates
  • 3D structure determination by X-ray diffraction analysis